PhysiVāntage Endure-X - Best Before June 2023

PLEASE NOTE: This product has a discounted price because it passed its best-before date in June 2023, though this will not reduce its efficacy.

Helping you improve your power endurance, stamina, and recovery, the PhysiVantage Endure-X is made up of all-natural ingredients (beetroot extract & citrulline malate), which have been shown in studies to give your endurance a boost via multiple ergogenic pathways.  Whether your looking to improve your climbing in a recreational sense, or are a professional at the top of your game, the PhysiVantage Endure-X gives you that extra performance edge you need when performing at your best.

Details:

- Performance-enhancing benefits while climbing and training:

- Improves Power Endurance on Routes and Boulder Problems

- Accelerates Recovery between High-Intensity Efforts

- Supports Optimal Blood Flow, Mitochondria Function, and O2 Kinetics- Supports Performance at Altitude

- NO Caffeine
- NO Artificial Colors
- NO Artificial Flavors
- 30 servings per unit (338 grams per container)  
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warning: May not be suitable for those with chronic migraines or kidney stones. Consult your medical doctor.

The Science:

- Beetroot and Citrulline Malate are two of the most-studied and effective performance-enhancing substances. As uniquely combined in Endure X, these two all-natural substances improve blood flow, oxygen kinetics, and muscle efficiency, thus increasing power endurance, recovery between intermittent high-intensity efforts, and performance at elevation.
- Beetroot extract (BE) is a rich source of nitrate reduced in vivo to nitrite and subsequently nitric oxide (NO). Elevating NO bioavailability improves body flow via vasodilation, most importantly in poorly perfused fast-twitch muscle fibers, elevates muscle oxygenation, and improves endothelia function. One study of healthy trained adults showed a 7.1% increased muscle efficiency (Larsen 2007), while another study showed a 15% increase in time to failure in high-intensity running (Lansley 2011) after 6 days of dietary nitrate—evidence that chronic supplementation forms a sort of “pool” of substrate that is used during exercise. A recent study of exercise performance at altitude showed that BE improved 3km time-trial performance by 4% compared with placebo (Shannon 2017). These, and many other, potential benefits of BE use are so significant that the Australian Institute of Sport (AIS) has graded it “Class A”—the highest level of evidence that a substance can improve exercise performance.
- Citrulline malate (CM) is a non-essential amino acid found in watermelon with potential benefits for power-endurance athletes, such as rock climbers, that may even exceed those of beetroot. The therapeutic and ergogenic effects of daily CM use have been studied extensively over the past 25 years, particularly in Spain where CM is sold as the pharmacologic Stimol (to treat physical fatigue, improve cognition, reduce muscle pain, and combat minor erectile dysfunction, among other things).
- Studies on CM use by athletes are many. Bendahan (2002) showed replenishment rate of ATP between bouts of high-intensity exercise was accelerated by 20%. Similarly impressive was a randomized, double-blind, placebo-controlled, crossover study performed by the Department of Medicine, University of Cordoba, Spain (Perez-Guisado 2010). The 41 subjects performed 16 sets of pectoral training at 80% of 1RM with just one minute of rest between sets—a real test of strength/power endurance! The CM group performed more repetitions from the third set onward and the increase in reps was positively correlated with the number of sets, such that on the final set the CM group averaged 53% more reps than the control group. Furthermore, the treatment group experienced 40% decrease in muscle soreness score at 24 and 48 hours post-exercise, compared to placebo. A 2019 meta-analysis published in the Journal of Sports Medicine analyzed 12 peer-review, placebo-controlled studies of CM (n=198) and found a “significant benefit for citrulline compared to placebo treatments”, although the effect size was small and the benefits would be most meaningful among elite athletes (Trexler 2019). Also noteworthy is an interesting study of female masters’ athletes that found a statistically significant increase in grip strength one hour after an acute dose of CM (Jordan 2016). Booyah!
- CM ergogenic pathways are many and researchers are still unwinding the details. In vivo, L-Citrulline is converted to L-Arginine and, in response to exercise, results in a sharp increase in nitric oxide (NO). Subsequent vasodilation allows for increased blood flow to active muscles, enhancing delivery of nutrients (and efflux of metabolic byproducts), augmenting contractile properties, and improving repair of muscle fibers (Petrovic 2008) during post-exercise recovery. Multiple studies have shown improved mitochondria function via modulation of the citric acid cycle (increase aerobic metabolism of lactate) and improved handling of ammonia (urea cycle)—these combined effect reduced O2 cost of exercise, thus slowing the burn rate of the finite anaerobic reserve and reducing the sensation of muscle fatigue. The bottom line: More studies than not show ergogenic effects of CM use especially in terms of time to failure during high-intensity exercises and most notably in events lasting 1 to 10 minutes. Performance benefits result from both acute and chronic supplementation of CM, and may be most meaningful among high-level athletes, masters athletes, and when exercising at elevation.
- Leveraging this wealth of research, Endure X is the first supplement to combine beetroot extract, citrulline malate, and betaine (a molecule found in beetroot sugar that may boost power) to create a synergistic endurance-enhancing pre-workout/pre-performance drink. Give it a try—it works!
- NOTE: Endure X ingredients are safe for competition as clarified and sanctioned by WADA, IOC, NCAA. The product is manufactured in a cGMP-certified and FDA-registered facility which tests each raw material and all finished products to validate the nutrition facts and vitamin & mineral label claims are met and other hazardous elements, such as microorganisms, are not present. Made in the USA.